The Science Behind Beautiful Skin

TR-OPC® is topical release oligomeric proanthocyanidins (OPC) produced by using a proprietary manufacturing method from Semillon grape seeds and made lipid soluble for use in topical applications for effective interaction with your skin. OPC has been clinically proven to protect cellular and tissue membranes by:

1. Neutralizing oxygen free radicals.
2. Chelating (absorbing) transition metals like iron, zinc, manganese and copper. These metals in ionic form can become dangerous “pro-oxidants” in the body.    
3. Blocks destructive enzymes, attachment to cellular receptors and/or modifying the cellular receptors’ response.

Unlike many other antioxidants and bio-flavonoids, TR-OPC® is fully bio-available, fat soluble and provides lasting healthful benefits. TR-OPC® penetrates both aqueous and lipid cellular membranes, an important factor in providing more complete cellular protection to the body’s tissues, skin and organs.

TOPICAL RELEASED.
The TR in TR-OPC® stands for 'topical released' and is produced using patented technology that enables the OPC to be fully activated and absorbed by skin tissue. When used daily its powerful rejuvenating effects are released and will scavenge free radicals continuously throughout the day.

ALL NATURAL.
Nu Visage® products are made from the most powerful botanical extracts and all natural ingredients. They work naturally with your body’s own maintenance and immune system to help stop free radical damage and restore youthful, radiant skin.

TR-OPC®, like vitamin C and many other essential nutrients, cannot be produced in our bodies and must be obtained from outside sources.  Although selectively derived from all-natural sources like grape seeds and pine bark, it is important to note that TR-OPC® and grape seed extract(s) are not the same, not even close.

TR-OPC® can only be obtained through a highly specialized, proprietary extraction process. Specifically, it is this highly selective process which yields potent, 100% bio-available TR-OPC®.

TR-OPC® AND VITAMIN C.
Vitamin C is essential for the maintenance of collagen’s elasticity and strength. Vitamin C helps build collagen by converting the amino acids lysine and proline into hydroxy lysine and hydroxy proline, the major amino acid forms found in collagen. TR-OPC® is an essential partner (co-factor) with vitamin C, and therefore helps to preserve collagen protein and maintain the health of the skin.

TR-OPC® also preserves vitamin C by blocking the formation of ascorbate oxidase; an enzyme that destroys vitamin C. Vitamin C can become a pro-oxidant if exposed to ionic iron, copper, and other minerals. TR-OPC® absorbs these metals before they can oxidize vitamin C, other antioxidants or body tissues.

As a co-factor to vitamin C, TR-OPC® acts to preserve vitamin C, an essential nutrient in the process of collagen biosynthesis. This is an important factor in maintaining the elasticity of the skin and the health of connective tissue.

TR-OPC®HAS AN AFFINITY FOR PROTEINS.
Unlike bioflavonoids, TR-OPC® attaches to collagen and elastin, especially those tissues rich in glycosaminoglycans. These include vascular and lymphatic membranes, stomach, gastrointestinal linings, sinus and respiratory systems and joint and vertebral support areas.   

TR-OPC® bonds with the proteins that form the vascular system walls. This thwarts cell destruction, while improving the healthy capillary’s selective passing of essential substances. TR-OPCTM protects intercellular structures, including the nuclear, mitochondrial, lysosomal and endoplasmic reticular membranes from free radical attack.  

TR-OPC® PROTECTS THE VASCULAR SYSTEM.
Healthy blood flow is essential to human health and life. TR-OPC® is scientifically proven to support the body in maintaining normal circulatory function. TR-OPC® strengthens capillary walls and micro-capillaries, improves capillary resistance and capillary leakage in the legs, eyes, and skin. TR-OPC® protects the vascular walls against the potentially harmful effects of cholesterol by inhibiting cholesterol deposits from forming on the elastin tissue of vascular walls.

Destructive enzymes can attack the arterial walls’ collagen structure. Free radicals further degenerate the cellular membranes and lesions occur. Low-density lipoproteins (LDL cholesterol) that have been oxidized by free radicals can easily get trapped in these lesions and attract calcium. These LDL/calcium deposits build-up and form “plaque” which narrows the artery encouraging blood clot formation.

TR-OPC® strengthens collagen against destructive enzymes and neutralizes free radicals, thus inhibiting LDL oxidation and plaque formation.


NU VISAGE SCIENTIFIC SUBSTANTIATION

Skin-Realted Studies:

Harmand, M.F. Blanquet, P. "The Fate of Total Flavanolic Oligomers (OFT) Extracted from ‘Vitus vinifera L.’ in the Rat" European Journal of Drug Metabolism and Pharmacokinetics. 1978, No. 1 pp. 15-30.

Delrieu, P., Ding J., Escande, B., Samain, D. "Free-radical Scavenging Activity of Proanthocyanidolic Oligomers Encapsulated in Glycospheres: an in Vivo and in Vitro Study." Cosmetology Department a & S Biovectors, Ramonville St. Agne France. pp. 1-9.

"Flavonoids et Pycnogenols" International Journal of Vitamin Nutrition Research (49)3;1979 pp. 307-311.


Anti-Aging and Antioxidant-Related Studies:

Laparra, J. Michaud, J. Masquelier, J. "Etude Pharmacocinetique des Oligomeres Flavonoliques" Plantes Medicinales et Phytotherapie, 1977 Tome XI, pp. 133-142.

Robert A.M.; Groult, N.; Six, C.; Robert, L. "Etude de l’Action des Oligomeres Procyanidoliques sur des Cellules          Mesenchymateuses en Culture. II l’Attachment des Fibres Elastiques aux Cellules." (Study of the effect of procyanidolic oligomers on mesenchymal cells in culture. II Attachment of elastic fibers to the cells) Pat. Biol.1990, (38)6, pp. 601-607.

Porter, Lawrence J., Wong Rosalind Y. Chan, Bock G. "The Molecular and Crystal Structure of (+)-2,3-trans- 3,4-trans-Leucocyanidin [(2R,3S,4R)-(+)-3,3', 4.4', 5.7'-Hexahydroxyflavan] Dihydrate, and Comparison of its Heterocyclic Ring Conformation in Solution and the Solid State." Journal of the Chemical Society, Perkin Transactions I 1985. pp. 1413-17.

Masquelier, Jacques "Proanthocyanidins et Radicaux Libres." "Radical Scavenger Effect (R.S.E.) of Proanthocyanidins." 1985.
        
Uchida, Shinji et al. "Condensed Tannins Scavenge Active Oxygen Free Radicals." Med. Sci. Res. (15) 1987. pp. 831-832.

Ariga, Toshiaki "Radical Scavenging Action and its Mode in Procyanidins B-1 and B-3 from Azuki Beans to Peroxyl Radicals." Agric. Biol. Chem. 54(10) 1990, pp. 2499-2504.

Da Silva, Ricardo et. al. "Radical Scavenger Capacity of Different Procyanidins from Grape Seeds." Presented at a symposium "Free Radicals in Biotechnology and Medicine." Royal Society of Chemistry, London January 1990, pp. 79-80.

Bauman, Joachim Wurm, Gotthard Bruchhausen, Franz "Hemmung der Prostaglandinsynthetase durch Flavonoide und Phenolderivate im Vergleich nit deren O2 Radikalfangereigenschaften" Arch. Pharm. (Weinheim) 313 (1980) pp. 330-337.

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